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Study by Professors Chen 和 Kong describes a novel 和 promising approach to overcome cancer drug resistance
February 21st 2022
Professors Chen 和 Kong with postdoctoral fellow Dr. Sudhir Bhatt.
The study led by Professors Hai-Lan Chen 和 Michael Kong from the Center for Bioelectrics, recently published in PNAS, shows the antitumor effects of trident cold atmospheric plasma (Tri-CAP), a reactive oxygen species-producing gas discharge. Tri-CAP simultaneously blocks three cancer survival pathways, including deregulated redox balance, glycolysis, 和 proliferative signaling, in a mouse cell line model of therapy-resistant chronic myeloid leukemia (CML). These effects trigger apoptotic cell death in CML cell lines 和 in primary CD34+ hematopoietic stem 和 progenitor cells from CML patients, while minimally affecting nonmalignant control cells. Tri-CAP also reduces tumor formation in vivo 和 prolonged the life of tumor-treated mice. To learn more ....