Batten Endowed Chair of 生物 and Professor of Electrical Engineering

电话: 757-683-7047

电子邮件: mkong@hebhgkq.com

地址: IRP 2, 4211 Monarch Way, Norfolk, VA, 23508

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Education

• 博士后: University of Nottingham, UK, 1993-1995
• 博士后: University of Liverpool, UK, 1992-1993
• Ph.D.: Electrical Engineering, University of Liverpool, UK, 1992.
• M.S.: Electronics Engineering, Zhejiang University, P R China, 1987
• B.S.: Electronics Engineering, Zhejiang University, P R China, 1984

实验室成员

李的选秀 实验室管理People员

JiaJun江, Ph.D. 学生. 与博士共同督导. C.H. 陈(ECE)和博士. M.G. 香港 (CBE及ECE)

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RESEARCH描述

Our laboratory is interested in science and engineering of cold atmospheric plasma (CAP), 它的生物效应, and their applications in medicine, 农业, 环境整治. Much of our research is empowered by redox chemistry of exogenous reactive and metastable molecules, 电子和离子, 光子, 瞬态电场, 和其他由CAP生产的. With modeling-guided precision engineering (Iza, Lee & 香港, 物理通讯(2009), we explore how best CAP can improve the current standard of care for multiple human disorders. Some of such opportunities are discussed in our review paper on plasma medicine. (香港 et al .; 新的J. 理论物理. 2009).

Our research shows that CAP deactivates infectious proteins (such as prions), bacteria in planktonic and biofilm states, fungi and virus (including those with spike protein such as SARS-CoV-2). An example of how these findings are translated to clinical settings is non-thermal decontamination of bacterial biofilm-contaminated endoscopes, 利用CAP的出水, we observe potent bacterial killing and biofilm disruption in gastrointestinal endoscopes of 2.2米长(巴特等People Gastrointest内窥镜检查 2019). 进一步, we are investigating how CAP may improve the outcome of hard-to-heal injuries, 比如慢性伤口, by boosting its potentiation of endogenous repair and regenerative processes of mammalian tissues.

A long-term research interest of our laboratory is cancer therapy that may improve the prognosis of patients who suffer from therapy resistance and disease progression. The ten cancer hallmarks (Hanahan & 温伯格 细胞 2011) represent the most fundamental pathways for cancer cell survival. Noting that many of these survival pathways are susceptible to regulation by reactive oxygen species (ROS), we search and explore a sweet spot where multiple cancer cell survival pathways may be downregulated by exogenous ROS and other effectors from CAP. This is shown to be possible in our recent discovery of CAP-mediated simultaneous blockade of three major cancer cell survival pathways and their crosstalks (Guo et al, PNAS 2021). We are testing this and other findings in clinically relevant model of cancer drug resistance.

用于临床翻译, CAP technologies have been used clinically for coagulation and tissue ablation and there have been clinical trials of CAP treatment of diabetic wounds and of head and neck tumor. In collaboration with clinical dermatologists, we undertook a randomized and controlled clinical trial of CAP-activated hydrogel treatment of vitiligo, an autoimmune skin disorder that affect ~1% of the world population. Data of this clinical trials show that 80% of patients with focal vitiligo achieved partial repigmentation and 20% achieved full repigmentation (Zhai et al, J. 投资. 北京医学. 2021).

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博士的一项RESEARCH. Chen and 香港 describes a novel and promising approach to overcome cancer drug resistance, see more ...

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最相关的出版物

1. 郭,B.波米特，A. D.，李，F.b、b、S.陈，C.黄，C.德宁格，M. W. 香港米. G. 和陈海.-C. Trident cold atmospheric plasma blocks three cancer survival pathways to overcome therapy resistance. Proc. 国家的. 阿德莱德大学. 美国科学 118, e2107220118 (2021).
2. 翟,年代.徐，M.李，Q.，郭，Q.郭，K.陈，H. L.孔，M. G. & 夏,Y. Successful treatment of vitiligo with cold atmospheric plasma-activated hydrogel. J. 皮肤病学RESEARCH 141, 2710-2719.e6 (2021).
3. Bhatt,年代.， Mehta, P.陈，C.施耐德，C.怀特，L.陈，H. L. & 香港毫克. Efficacy of low-temperature plasma activated gas disinfection against biofilm on contaminated GI endoscope channels. 胃肠内镜 89, 105 - 114. (2019).
4. 现,F.李，J. K. & 香港米. G. Electron kinetics in radio-frequency atmospheric-pressure microplasmas. 理论物理. 牧师. 列托语. 99, 075004 (2007).
5. 香港米. G.克鲁森，G.莫菲尔，G. Nosenko T. 清水,T.范戴克，J. 齐默尔曼，J. L. Plasma Medicine: an Introductory 牧师iew. 新的J. 理论物理. 11, 115012 (2009).

奖项及荣誉

• 国际 Society for Plasma Medicine Award (2010)
• Fellow of Institute of Electrical and Electronics Engineers (IEEE) (2012).
• IEEE Plasma Science and Application Exceptional 服务 Award (2012)
• IEEE Nuclear and Plasma Sciences Merit Award (2015)
• Chair, IEEE Plasma Science and Application ExCom (2017-18)
• Advisory Board for the m/q Initiative, Pacific Northwest National Laboratory, USA (2018-20)
• In the top 2% of most-cited scientists in his field in 2020 - 斯坦福大学RESEARCH